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Article

An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin.

Human genetics - 1 Dec 2005

Bernig Toralf, Breunis Willemijn, Brouwer Nannette, Hutchinson Amy, Welch Robert, Roos Dirk, Kuijpers Taco, Chanock Stephen

Abstract excerpt

Mannose-binding protein (MBL) is a critical component of innate immunity and provides first-line protection against pathogens. Both circulating MBL serum levels and functional activity have been correlated with common genetic variants in the MBL2 gene. Associations between MBL deficiency and severe infections have been reported in immuno-incompetent patients and for autoimmune disorders; however, measured MBL...

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Source

Identifiers

PMID: 16208516
DOI: 10.1007/s00439-005-0053-5

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin.PMID 16208516Read ↗

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