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Article

Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles.

Human molecular genetics - 1 Sept 2006

Verdu Paul, Barreiro Luis B, Patin Etienne, Gessain Antoine, Cassar Olivier, Kidd Judith R, Kidd Kenneth K, Behar Doron M, Froment Alain, Heyer Evelyne, Sica Lucas, Casanova Jean-Laurent, Abel Laurent, Quintana-Murci Lluís

Abstract excerpt

Human mannose-binding lectin (MBL) is a member of the collectin protein family that binds a broad range of microorganisms and activates the lectin-complement pathway of innate immunity. Common alleles of MBL2 disrupt the MBL protein or modulate the amount of protein produced, resulting in MBL deficiency. The clinical manifestations of MBL deficiency have been extensively studied but the actual role of this lectin...

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Source

Identifiers

PMID: 16885193
DOI: 10.1093/hmg/ddl193

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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