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Article

Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations.

Human genetics - 1 May 2014

Wang Shaolin, D van der Vaart Andrew, Xu Qing, Seneviratne Chamindi, Pomerleau Ovide F, Pomerleau Cynthia S, Payne Thomas J, Ma Jennie Z, Li Ming D

Abstract excerpt

The direct physiological effects that promote nicotine dependence (ND) are mediated by nicotinic acetylcholine receptors (nAChRs). In line with the genetic and pharmacological basis of addiction, many previous studies have revealed significant associations between variants in the nAChR subunit genes and various measures of ND in different ethnic samples. In this study, we first examined the association of...

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Identifiers

PMID: 24253422
DOI: 10.1007/s00439-013-1398-9
PMCID: PMC3988215

Genes

CHRNA2
CHRNA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations.PMID 24253422Read ↗

Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence.Semantic proximity Read ↗

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.Semantic proximity Read ↗

Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.Semantic proximity Read ↗

Nominal association with CHRNA4 variants and nicotine dependence.Semantic proximity Read ↗

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Semantic proximity Read ↗

Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.Semantic proximity Read ↗

Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.Semantic proximity Read ↗

Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.Semantic proximity Read ↗

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Semantic proximity Read ↗

Possible association of nicotinic acetylcholine receptor gene (CHRNA4 and CHRNB2) polymorphisms with nicotine dependence in Japanese males: an exploratory study.Semantic proximity Read ↗

Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.Semantic proximity Read ↗

Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.Semantic proximity Read ↗

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