Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence.

Human molecular genetics - 1 May 2005

Li Ming D, Beuten Joke, Ma Jennie Z, Payne Thomas J, Lou Xiang-Yang, Garcia Veronica, Duenes Aristeo S, Crews Karen M, Elston Robert C

Abstract excerpt

We tested six single nucleotide polymorphisms (SNPs) in the alpha4 subunit gene (CHRNA4) and four SNPs in the beta2 subunit gene (CHRNB2) of nicotinic acetylcholine receptors (nAChRs) for association with nicotine dependence (ND), which was assessed by smoking quantity (SQ), the heaviness of smoking index (HSI) and the Fagerstrom test for ND (FTND) in 2037 subjects from 602 nuclear families of either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Receptors, Nicotinic

Share to Sex Characteristics

Share to Smoking

Share to Tobacco Use Disorder

Share to White People

Source

Identifiers

PMID: 15790597
DOI: 10.1093/hmg/ddi132

Genes

CHRNA4
CHRNB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence.PMID 15790597Read ↗

Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations.Semantic proximity Read ↗

Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans.Semantic proximity Read ↗

Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.Semantic proximity Read ↗

Association of nicotinic acetylcholine receptor subunit alpha-4 polymorphisms with smoking behaviors in Chinese male smokers.Semantic proximity Read ↗

Possible association of nicotinic acetylcholine receptor gene (CHRNA4 and CHRNB2) polymorphisms with nicotine dependence in Japanese males: an exploratory study.Semantic proximity Read ↗

Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.Semantic proximity Read ↗

Nominal association with CHRNA4 variants and nicotine dependence.Semantic proximity Read ↗

Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions.Semantic proximity Read ↗

Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.Semantic proximity Read ↗

The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to TherapeuticsSemantic proximity Read ↗

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.Semantic proximity Read ↗

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.