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Article

Nominal association with CHRNA4 variants and nicotine dependence.

Genes, brain, and behavior - 1 Apr 2013

Kamens H M, Corley R P, McQueen M B, Stallings M C, Hopfer C J, Crowley T J, Brown S A, Hewitt J K, Ehringer M A

Abstract excerpt

Nicotine binds to nicotinic acetylcholine receptors and studies in animal models have shown that α4β2 receptors mediate many behavioral effects of nicotine. Human genetics studies have provided support that variation in the gene that codes for the α4 subunit influences nicotine dependence (ND), but the evidence for the involvement of the β2 subunit gene is less convincing. In this study, we examined the genetic...

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Source

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Identifiers

PMID: 23350800
DOI: 10.1111/gbb.12021
PMCID: PMC3727281

Genes

CHRNA4
CHRNB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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