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Article

Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.

Human molecular genetics - 1 Jun 2008

Nussbaum Justin, Xu Qing, Payne Thomas J, Ma Jennie Z, Huang Weihua, Gelernter Joel, Li Ming D

Abstract excerpt

The neurexin-1 gene (NRXN1) has been shown to play a fundamental role in synaptogenesis and synaptic maintenance, as well as Ca(2+) channel and NMDA receptor recruitment. A recent study reported that NRXN1 is associated with nicotine dependence (ND); this, together with the intriguing physiological functions of the gene, motivated us to investigate the involvement of NRXN1 with ND in independent samples. In this...

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Source

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Identifiers

PMID: 18270208
DOI: 10.1093/hmg/ddn044
PMCID: PMC2902291

Genes

NRXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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