Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells

Abstract excerpt

BACKGROUND: Expression of the urokinase plasminogen activator receptor (UPAR) has been shown to have clinical relevance in various cancers. We have recently identified UPAR as an asthma susceptibility gene and there is evidence to suggest that uPAR may be upregulated in lung diseases such as COPD and asthma. uPAR is a key receptor involved in the formation of the serine protease plasmin by interacting with uPA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood Coagulation and Thrombosis Mechanisms
• Share to Oral microbiology and periodontitis research
• Share to Protease and Inhibitor Mechanisms