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Article

Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions

15 May 2008

Abstract excerpt

Human tissue kallikreins (KLKs) are the largest family of secreted serine protease endopeptidases encoded by 15 genes clustered on chromosome 19q13.4. Multiple KLK enzymes are co-localized in the upper stratum granulosum and stratum corneum of human epidermis, and in associated appendages such as hair follicle epithelia and sweat glands. Until recently, kallikrein proteolytic activity in the skin was exclusively...

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Identifiers

PMID: 18627299
DOI: 10.1515/bc.2008.079

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