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Article

Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing.

Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2013

Skurnik David, Roux Damien, Cattoir Vincent, Danilchanka Olga, Lu Xi, Yoder-Himes Deborah R, Han Kook, Guillard Thomas, Jiang Deming, Gaultier Charlotte, Guerin François, Aschard Hugues, Leclercq Roland, Mekalanos John J, Lory Stephen, Pier Gerald B

Abstract excerpt

An important question regarding the biologic implications of antibiotic-resistant microbes is how resistance impacts the organism's overall fitness and virulence. Currently it is generally thought that antibiotic resistance carries a fitness cost and reduces virulence. For the human pathogen Pseudomonas aeruginosa, treatment with carbapenem antibiotics is a mainstay of therapy that can lead to the emergence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24248354
DOI: 10.1073/pnas.1221552110
PMCID: PMC3870709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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