Article
Further evidence for the impact of a genome-wide-supported psychosis risk variant in ZNF804A on the Theory of Mind Network.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2014
Mohnke Sebastian, Erk Susanne, Schnell Knut, Schütz Claudia, Romanczuk-Seiferth Nina, Grimm Oliver, Haddad Leila, Pöhland Lydia, Garbusow Maria, Schmitgen Mike M, Kirsch Peter, Esslinger Christine, Rietschel Marcella, Witt Stephanie H, Nöthen Markus M, Cichon Sven, Mattheisen Manuel, Mühleisen Thomas, Jensen Jimmy, Schott Björn H, Maier Wolfgang, Heinz Andreas, Meyer-Lindenberg Andreas, Walter Henrik
Abstract excerpt
The single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A is one of the best-supported risk variants for psychosis. We hypothesized that this SNP contributes to the development of schizophrenia by affecting the ability to understand other people's mental states. This skill, commonly referred to as Theory of Mind (ToM), has consistently been found to be impaired in schizophrenia. Using functional magnetic...
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