Article
The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2011
Voineskos Aristotle N, Lerch Jason P, Felsky Daniel, Tiwari Arun, Rajji Tarek K, Miranda Dielle, Lobaugh Nancy J, Pollock Bruce G, Mulsant Benoit H, Kennedy James L
Abstract excerpt
Schizophrenia and bipolar disorder share genetic risk, brain vulnerability, and clinical symptoms. The ZNF804A risk variant, rs1344706, confers susceptibility for both disorders. This study aimed to identify neural mechanisms common to both schizophrenia and bipolar disorder through this variant's potential effects on cortical thickness, white matter tract integrity, and cognitive function. Imaging, genetics, and...
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