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Article

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.

Human molecular genetics - 15 Jul 2015

Boddu Ravindra, Hull Travis D, Bolisetty Subhashini, Hu Xianzhen, Moehle Mark S, Daher João Paulo Lima, Kamal Ahmed Ibrahim, Joseph Reny, George James F, Agarwal Anupam, Curtis Lisa M, West Andrew B

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common known genetic cause of Parkinson's disease, and LRRK2 is also linked to Crohn's and Hansen's disease. LRRK2 is expressed in many organs in mammals but is particularly abundant in the kidney. We find that LRRK2 protein is predominantly localized to collecting duct cells in the rat kidney, with much lower expression in other kidney...

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Identifiers

PMID: 25904107
DOI: 10.1093/hmg/ddv147
PMCID: PMC4476452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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