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Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.

Toxicologic pathology - 1 Jan 2023

Gu Yi-Zhong, Vlasakova Katerina, Miller Glen, Gatto Nicholas T, Ciaccio Paul J, Kuruvilla Sabu, Besteman Elizabeth G, Smith Roger, Reynolds Spencer J, Amin Rupesh P, Glaab Warren E, Wollenberg Gordon, Lebron Jose, Sistare Frank D

Abstract excerpt

Activating mutations of the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson disease (PD), prompting development of LRRK2 inhibitors as potential treatment for PD. However, kidney safety concerns have surfaced from LRRK2 knockout (KO) mice and rats and from repeat-dose studies in rodents administered LRRK2 inhibitors. To support drug development of this therapeutic target, we conducted a...

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PMID: 37078689
DOI: 10.1177/01926233231162809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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