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Article

DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.

Clinical epigenetics - 16 Dec 2019

Noreen Faiza, Küng Taya, Tornillo Luigi, Parker Hannah, Silva Miguel, Weis Stefan, Marra Giancarlo, Rad Roland, Truninger Kaspar, Schär Primo

Abstract excerpt

BACKGROUND: Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. Here, we aimed to dissect CC subtype-specific methylation instability to understand underlying mechanisms and functions. METHODS: We have assessed genome-wide DNA methylation in the healthy...

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Identifiers

PMID: 31842975
DOI: 10.1186/s13148-019-0791-1
PMCID: PMC6916434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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