Article
Prefrontal dopamine levels determine the balance between cognitive stability and flexibility.
Cerebral cortex (New York, N.Y. : 1991) - 1 Feb 2013
Fallon S J, Williams-Gray C H, Barker R A, Owen A M, Hampshire A
Abstract excerpt
A key mechanism by which the prefrontal cortex (PFC) supports goal-oriented behaviors is attentional set formation: the formation and maintenance of an attentional bias toward relevant features. It has previously been proposed that a common single nucleotide polymorphism (val158met) in the gene that codes for the catechol O-methyltransferase (COMT) enzyme may affect an individual's ability to form and maintain an...
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