Article
Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection.
Cell reports - 9 Jun 2020
Skarlatou Sophie, Hérent Coralie, Toscano Elisa, Mendes César S, Bouvier Julien, Zampieri Niccolò
Abstract excerpt
Afadin, a scaffold protein controlling the activity of the nectin family of cell adhesion molecules, regulates important morphogenetic processes during development. In the central nervous system, afadin has critical roles in neuronal migration, axonal elongation, and synapse formation. Here we examine the role of afadin in development of spinal motor circuits. Afadin elimination in motor neuron progenitors...
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