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Article

Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.

Development (Cambridge, England) - 13 Jul 2020

Lough Kendall J, Spitzer Danielle C, Bergman Abby J, Wu Jessica J, Byrd Kevin M, Williams Scott E

Abstract excerpt

Cleft palate (CP), one of the most common congenital conditions, arises from failures in secondary palatogenesis during embryonic development. Several human genetic syndromes featuring CP and ectodermal dysplasia have been linked to mutations in genes regulating cell-cell adhesion, yet mouse models have largely failed to recapitulate these findings. Here, we use in utero lentiviral-mediated genetic approaches in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32554531
DOI: 10.1242/dev.189241
PMCID: PMC7375477

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CP

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