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Article

Sex-Specific Hippocampal Phosphoproteomic Features Associated with Stress-Induced Phenotypes in Mice Exposed to Chronic Restraint Stress.

Neurochemical research - 20 Jun 2026

Liu Yanchen, Wang Tingting, Zhao Wenjing, Yang Chen, Zhao Yuxi, Lu Fengmei, Cai Xiao, Wang Lili, Li Shuiming, Zhou Jian, He Zongling

Abstract excerpt

Chronic stress significantly contributes to anxiodepression, with marked sex differences in hippocampal dysfunction. This study investigated the interplay between sex and stress phenotype in shaping hippocampal phosphorylation landscapes in a chronic restraint stress model of anxiodepression. Hippocampal phosphoproteomes of female and male mice, classified as anxiodepression-susceptible (AD-Sus) and insusceptible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42322444
DOI: 10.1007/s11064-026-04819-2

Genes

MAPK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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