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Article

Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites.

The Journal of biological chemistry - 17 Dec 2004

Fabbretti Elsa, Sokolova Elena, Masten Lara, D'Arco Marianna, Fabbro Alessandra, Nistri Andrea, Giniatullin Rashid

Abstract excerpt

On nociceptive neurons, one important mechanism to generate pain signals is the activation of P2X(3) receptors, which are membrane proteins gated by extracellular ATP. In the presence of the agonist, P2X(3) receptors rapidly desensitize and then recover slowly. One unique property of P2X(3) recep...

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Identifiers

PMID: 15475563
DOI: 10.1074/jbc.M409772200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15475563-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites.PMID 15475563Read ↗

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