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Article

Use-dependent inhibition of P2X3 receptors by nanomolar agonist.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Aug 2005

Pratt Emily B, Brink Thaddeus S, Bergson Pamela, Voigt Mark M, Cook Sean P

Abstract excerpt

P2X3 receptors desensitize within 100 ms of channel activation, yet recovery from desensitization requires several minutes. The molecular basis for this slow rate of recovery is unknown. We designed experiments to test the hypothesis that this slow recovery is attributable to the high affinity (< 1 nM) of desensitized P2X3 receptors for agonist. We found that agonist binding to the desensitized state provided a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16093386
DOI: 10.1523/JNEUROSCI.5189-04.2005
PMCID: PMC6725291

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Use-dependent inhibition of P2X3 receptors by nanomolar agonist.PMID 16093386Read ↗

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