Article
Intestinal DMBT1 expression is modulated by Crohn's disease-associated IL23R variants and by a DMBT1 variant which influences binding of the transcription factors CREB1 and ATF-2.
PloS one - 1 Jan 2013
Diegelmann Julia, Czamara Darina, Le Bras Emmanuelle, Zimmermann Eva, Olszak Torsten, Bedynek Andrea, Göke Burkhard, Franke Andre, Glas Jürgen, Brand Stephan
Abstract excerpt
OBJECTIVES: DMBT is an antibacterial pattern recognition and scavenger receptor. In this study, we analyzed the role of DMBT1 single nucleotide polymorphisms (SNPs) regarding inflammatory bowel disease (IBD) susceptibility and examined their functional impact on transcription factor binding and downstream gene expression. METHODS: Seven SNPs in the DMBT1 gene region were analyzed in 2073 individuals including 818...
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