Article
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.
Gastroenterology - 1 Aug 2013
Ellinghaus David, Zhang Hu, Zeissig Sebastian, Lipinski Simone, Till Andreas, Jiang Tao, Stade Björn, Bromberg Yana, Ellinghaus Eva, Keller Andreas, Rivas Manuel A, Skieceviciene Jurgita, Doncheva Nadezhda T, Liu Xiao, Liu Qing, Jiang Fuman, Forster Michael, Mayr Gabriele, Albrecht Mario, Häsler Robert, Boehm Bernhard O, Goodall Jane, Berzuini Carlo R, Lee James, Andersen Vibeke, Vogel Ulla, Kupcinskas Limas, Kayser Manfred, Krawczak Michael, Nikolaus Susanna, Weersma Rinse K, Ponsioen Cyriel Y, Sans Miquel, Wijmenga Cisca, Strachan David P, McArdle Wendy L, Vermeire Séverine, Rutgeerts Paul, Sanderson Jeremy D, Mathew Christopher G, Vatn Morten H, Wang Jun, Nöthen Markus M, Duerr Richard H, Büning Carsten, Brand Stephan, Glas Jürgen, Winkelmann Juliane, Illig Thomas, Latiano Anna, Annese Vito, Halfvarson Jonas, D'Amato Mauro, Daly Mark J, Nothnagel Michael, Karlsen Tom H, Subramani Suresh, Rosenstiel Philip, Schreiber Stefan, Parkes Miles, Franke Andre
Abstract excerpt
BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies. METHODS: We sequenced whole exomes of...
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