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Article

Antibody biomarker discovery through in vitro directed evolution of consensus recognition epitopes

12 Nov 2013

Abstract excerpt

To enable discovery of serum antibodies indicative of disease and simultaneously develop reagents suitable for diagnosis, in vitro directed evolution was applied to identify consensus peptides recognized by patients' serum antibodies. Bacterial cell-displayed peptide libraries were quantitatively screened for binders to serum antibodies from patients with celiac disease (CD), using cell-sorting instrumentation to...

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PMID: 24222690
DOI: 10.1073/pnas.1314792110

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