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Article

Impact of interleukin-10 on phenotype and gene expression during early monocyte differentiation into dendritic cells.

Anticancer research - 1 Nov 2013

Schwarz Annika M, Banning-Eichenseer Ursula, Seidel Kerstin, Mauz-Körholz Christine, Körholz Dieter, Staege Martin S

Abstract excerpt

BACKGROUND: Cancer is linked to defects in immunosurveillance. Vaccination studies using dendritic cells (DC) try to re-establish immune responses toward tumor cells. Tumor-derived products such as interleukin-10 (IL-10) have inhibitory effects on DC function, and tumor-bearing hosts exhibit a lower number of DCs, suggesting inhibitory effects of tumor-derived factors on the recruitment of precursor cells....

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PMID: 24222115

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