Article
IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.
Oncotarget - 10 Jan 2017
Llopiz Diana, Ruiz Marta, Infante Stefany, Villanueva Lorea, Silva Leyre, Hervas-Stubbs Sandra, Alignani Diego, Guruceaga Elizabeth, Lasarte Juan J, Sarobe Pablo
Abstract excerpt
Vaccination induces immunostimulatory signals that are often accompanied by regulatory mechanisms such as IL-10, which control T-cell activation and inhibit vaccine-dependent antitumor therapeutic effect. Here we characterized IL-10-producing cells in different tumor models treated with therapeutic vaccines. Although several cell subsets produced IL-10 irrespective of treatment, an early vaccine-dependent...
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