Article
Increased levels of interleukin-10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2004
Beckebaum Susanne, Zhang Xia, Chen Xiao, Yu Zhengya, Frilling Andrea, Dworacki Grzegorz, Grosse-Wilde Hans, Broelsch Christoph Erich, Gerken Guido, Cicinnati Vito R
Abstract excerpt
Increased levels of interleukin (IL)-10 have been described as a negative prognostic indicator for survival in patients with various types of cancer. IL-10 exerts tolerogenic and immunosuppressive effects on dendritic cells, which are crucial for the induction of an antitumor immune response. Blo...
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