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Article

Enhancer turnover and conserved regulatory function in vertebrate evolution.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Dec 2013

Domené Sabina, Bumaschny Viviana F, de Souza Flávio S J, Franchini Lucía F, Nasif Sofía, Low Malcolm J, Rubinstein Marcelo

Abstract excerpt

Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in the sequence, arrangement and repertoire of transcription factor binding sites, but whole enhancers can also be lost or gained in certain lineages in a process of turnover. The proopiomelanocortin gene (Pomc), which encodes a prohormone, is expressed in the...

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Share to Animals, Genetically Modified
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24218639
DOI: 10.1098/rstb.2013.0027
PMCID: PMC3826500

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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