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Article

Functionally conserved enhancers with divergent sequences in distant vertebrates.

BMC genomics - 30 Oct 2015

Yang Song, Oksenberg Nir, Takayama Sachiko, Heo Seok-Jin, Poliakov Alexander, Ahituv Nadav, Dubchak Inna, Boffelli Dario

Abstract excerpt

BACKGROUND: To examine the contributions of sequence and function conservation in the evolution of enhancers, we systematically identified enhancers whose sequences are not conserved among distant groups of vertebrate species, but have homologous function and are likely to be derived from a common ancestral sequence. Our approach combined comparative genomics and epigenomics to identify potential enhancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26519295
DOI: 10.1186/s12864-015-2070-7
PMCID: PMC4628251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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