Article
Comparison of diverged Hoxc8 early enhancer activities reveals modification of regulatory interactions at conserved cis-acting elements.
Journal of experimental zoology. Part B, Molecular and developmental evolution - 15 May 2007
Shashikant Cooduvalli S, Bolanowsky Stacey A, Anand Sanjay, Anderson Shawn M
Abstract excerpt
The Hoxc8 early enhancer that controls the initiation and establishment of Hoxc8 expression in the developing mouse embryo is found in different vertebrate lineages including mammals, birds and fish. Mouse and Fugu Hoxc8 early enhancers (200 bp) have diverged in the composition of elements located towards the 3' region. However, they share cis-acting elements A-E located in the 5' region. Mutations at these...
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