Article
Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification.
Developmental biology - 15 Apr 2011
Fujimoto Esther, Stevenson Tamara J, Chien Chi-Bin, Bonkowsky Joshua L
Abstract excerpt
The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specification of neuronal identity, connectivity, and function in the basal ganglia. Based primarily on...
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