Article
Assessing constraints on the path of regulatory sequence evolution.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Dec 2013
Glassford William J, Rebeiz Mark
Abstract excerpt
Structural and functional constraints are known to play a major role in restricting the path of evolution of protein activities. However, constraints acting on evolving transcriptional regulatory sequences, e.g. enhancers, are largely unknown. Recently, we elucidated how a novel expression pattern of the Neprilysin-1 (Nep1) gene in the optic lobe of Drosophila santomea evolved via co-option of existing enhancer...
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