Article

The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway

2023-10-27

Abstract excerpt

Precise control of protein ubiquitination is essential for brain development, and hence, disruption of ubiquitin signaling networks can lead to neurological disorders. Mutations of the deubiquitinase USP7 cause the Hao-Fountain syndrome (HAFOUS), characterized by developmental delay, intellectual disability, autism, and aggressive behavior. Here, we report that conditional deletion of USP7 in excitatory neurons in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37842089-a458-59d3-9eb7-d4e142a71ad2
DOI: 10.1101/2023.10.24.563880

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathwayDOI 10.1101/2023.10.24.563880Read

Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1Semantic proximity Read

Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome.Semantic proximity Read

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.Semantic proximity Read

Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome: Figure 1Semantic proximity Read

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseasesSemantic proximity Read

Biallelic USP14 variants cause a syndromic neurodevelopmental disorder.Semantic proximity Read

A Upf3b-mutant mouse model with behavioral and neurogenesis defects.Semantic proximity Read

Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in diseaseSemantic proximity Read

The Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3ccSemantic proximity Read

Implications of FBXW7 in Neurodevelopment and Neurodegeneration: Molecular Mechanisms and Therapeutic PotentialSemantic proximity Read

Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14).Semantic proximity Read