Article

Suppression of p16 alleviates the senescence-associated secretory phenotype

2020-08-19

Abstract excerpt

Oncogene induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis. OIS cells are also characterized by the expression and secretion of a widely variable group of factors collectively termed the senescence-associated secretory...

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Literature Corpus work: 83416c5b-0850-5906-a71d-b5365537d8b9
DOI: 10.1101/2020.08.19.257717

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