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Article

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.

Nature cell biology - 26 Feb 2012

Benhamed Moussa, Herbig Utz, Ye Tao, Dejean Anne, Bischof Oliver

Abstract excerpt

Cellular senescence is a tumour-suppressor mechanism that is triggered by cancer-initiating or promoting events in mammalian cells. The molecular underpinnings for this stable arrest involve transcriptional repression of proliferation-promoting genes regulated by the retinoblastoma (RB1)/E2F repressor complex. Here, we demonstrate that AGO2, RB1 and microRNAs (miRNAs), as exemplified here by let-7, physically and...

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Source

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Identifiers

PMID: 22366686
DOI: 10.1038/ncb2443
PMCID: PMC5423543

Genes

AGO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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