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Article

MicroRNAs Regulate Key Effector Pathways of Senescence

1 Jan 2011

Abstract excerpt

MicroRNAs (miRNAs) are small (approximately 22 nt) noncoding endogenous RNA molecules that regulate gene expression and protein coding by base pairing with the 3' untranslated region (UTR) of target mRNAs. miRNA expression is associated with cancer pathogenesis because miRNAs are intimately linked to cancer development. Senescence blocks cell proliferation, representing an important barrier that cells must bypass...

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PMID: 21629746
DOI: 10.4061/2011/205378

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