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Article

DNA Methylation and the HOXC6 Paradox in Prostate Cancer

27 Sept 2011

Abstract excerpt

Overexpression of the classical homeobox transcription factor HOXC6 is frequent in prostate cancers and correlates with adverse clinical parameters. Since surprisingly many HOXC6 target genes are downregulated in prostate cancer, it has been posited that oncogenic effects of HOXC6 in prostate cancer may be unmasked by concurrent epigenetic downregulation of target genes exerting tumor suppressive effects. To test...

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PMID: 24213107
DOI: 10.3390/cancers3043714

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