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HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directions

16 Feb 2017

Abstract excerpt

The recent and exciting discovery of germline HOXB13 mutations in familial prostate cancer has brought HOX signaling to the forefront of prostate cancer research. An enhanced understanding of HOX signaling, and the co-factors regulating HOX protein specificity and transcriptional regulation, has the high potential to elucidate novel approaches to prevent, diagnose, stage, and treat prostate cancer. Toward our...

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PMID: 28798948
DOI: 10.1016/j.gendis.2017.01.003

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