Article

RFX6 at locus 6q22 confers metastasis and drug resistance in prostate cancer

2024-01-09

Abstract excerpt

Genetic and nonmutational epigenetic alterations are cancer hallmark characteristics. However, the role of inherited cancer predisposition alleles in co-opting lineage factor epigenetic reprogramming and contributing to tumor progression remains elusive. Here the FinnGen cohort phenome-wide analysis, along with recent multiple genome-wide association studies, has consistently identified the rs339331-RFX6/6q22 locu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db1456a0-1d49-5a75-80f0-661f41991779
DOI: 10.1101/2024.01.08.574758

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RFX6 at locus 6q22 confers metastasis and drug resistance in prostate cancerDOI 10.1101/2024.01.08.574758Read

An Inherited Allele Confers Prostate Cancer Progression and Drug Resistance via RFX6/HOXA10-Orchestrated TGFβ Signaling.Semantic proximity Read

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.Semantic proximity Read

HOXB13, RFX6 and prostate cancer risk.Semantic proximity Read

GATA2 co-opts TGFβ1/SMAD4 oncogenic signaling and inherited variants at 6q22 to modulate prostate cancer progressionSemantic proximity Read

The splicing factor SRSF6 regulates AR activity and represents a potential therapeutic target in prostate cancerSemantic proximity Read

AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancerSemantic proximity Read

Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancerSemantic proximity Read

An Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor ProgressionSemantic proximity Read

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.Semantic proximity Read

Identifying Potential Drug Targets for Prostate Cancer from a Genetic Perspective: A Mendelian Randomization StudySemantic proximity Read

Genetic wiring of the m6A epitranscriptome drives prostate cancer progressionSemantic proximity Read

Role of the runt‐related transcription factor (RUNX) family in prostate cancerSemantic proximity Read