An Inherited Allele Confers Prostate Cancer Progression and Drug Resistance via RFX6/HOXA10-Orchestrated TGFβ Signaling.

doi:10.1002/advs.202401492

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An Inherited Allele Confers Prostate Cancer Progression and Drug Resistance via RFX6/HOXA10-Orchestrated TGFβ Signaling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2024

Zhong Mengjie, Xu Wenjie, Tian Pan, Zhang Qin, Wang Zixian, Liang Limiao, Zhang Qixiang, Yang Yuehong, Lu Ying, Wei Gong-Hong

Abstract excerpt

Genetic and epigenetic alterations are cancer hallmark characteristics. However, the role of inherited cancer predisposition alleles in co-opting lineage factor epigenetic reprogramming and tumor progression remains elusive. Here the FinnGen cohort phenome-wide analysis, along with multiple genome-wide association studies, has consistently identified the rs339331-RFX6/6q22 locus associated with prostate cancer...

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PMID: 38932472
DOI: 10.1002/advs.202401492
PMCID: PMC11348203

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