Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HOXB13, RFX6 and prostate cancer risk.

Nature genetics - 1 Feb 2014

Mills Ian G

Abstract excerpt

A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Chromosomes, Human, Pair 6
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Homeodomain Proteins

Share to Prostatic Neoplasms

Share to Regulatory Factor X Transcription Factors

Share to Transcription Factors

Source

Identifiers

PMID: 24473320
DOI: 10.1038/ng.2881

Genes

HOXB13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HOXB13, RFX6 and prostate cancer risk.PMID 24473320Read ↗

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.Semantic proximity Read ↗

RFX6 at locus 6q22 confers metastasis and drug resistance in prostate cancerSemantic proximity Read ↗

An Inherited Allele Confers Prostate Cancer Progression and Drug Resistance via RFX6/HOXA10-Orchestrated TGFβ Signaling.Semantic proximity Read ↗

HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directionsSemantic proximity Read ↗

Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.Semantic proximity Read ↗

A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13.Semantic proximity Read ↗

Germline Mutations in HOXB13 and Prostate-Cancer RiskSemantic proximity Read ↗

HOXB13 and other high penetrant genes for prostate cancer.Semantic proximity Read ↗

Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer.Semantic proximity Read ↗

Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathwaySemantic proximity Read ↗

Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness.Semantic proximity Read ↗

HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.