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Article

Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis.

Rheumatology international - 1 May 2014

Huang Chun-Huang, Wei James Cheng-Chung, Chen Chun-Chieh, Chuang Chih-Shien, Chou Chia-Hsuan, Lin Yu-Jie, Wang Ming-Fuu, Wong Ruey-Hong

Abstract excerpt

Ankylosing spondylitis (AS) is an autoimmune disease, and the imbalance of peripheral tolerance is involved in its pathogenesis. Importantly, the negative signal of activated T cells plays a crucial role in the balance of peripheral tolerance. It has been postulated that human protein tyrosine phosphatase nonreceptor 22 (PTPN22) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) genes encode proteins that are actively...

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Source

Identifiers

PMID: 24212676
DOI: 10.1007/s00296-013-2894-x

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis.PMID 24212676Read ↗

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The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review.Semantic proximity Read ↗

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