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Article

Effects of genetic polymorphisms of programmed cell death 1 and its ligands on the development of ankylosing spondylitis.

Rheumatology (Oxford, England) - 1 Oct 2011

Huang Chun-Huang, Wong Ruey-Hong, Wei James Cheng-Chung, Tsay Ming-Dow, Chen Wei-Chiao, Chen Hung-Yin, Shih Wei-Ting, Chiou Sz-Ping, Tu Yi-Chung, Lee Hong-Shen

Abstract excerpt

OBJECTIVES: There is a known association of imbalanced peripheral tolerance and autoimmune diseases. The binding of programmed cell death 1 (PD-1) with its ligands 1 and 2 (PD-L1 and PD-L2) inhibits T-cell proliferation through a negative signal via recruitment of src homology 2-domain-containing tyrosine phosphatase 2. Therefore we evaluated the effect of the PD-1, PD-L1 and PD-L2 genotypes on the occurrence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21791547
DOI: 10.1093/rheumatology/ker211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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