Article
Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data.
PloS one - 1 Jan 2013
Bryzgalov Leonid O, Antontseva Elena V, Matveeva Marina Yu, Shilov Alexander G, Kashina Elena V, Mordvinov Viatcheslav A, Merkulova Tatyana I
Abstract excerpt
A vast amount of SNPs derived from genome-wide association studies are represented by non-coding ones, therefore exacerbating the need for effective identification of regulatory SNPs (rSNPs) among them. However, this task remains challenging since the regulatory part of the human genome is annotated much poorly as opposed to coding regions. Here we describe an approach aggregating the whole set of ENCODE ChIP-seq...
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