Article
Integrating regulatory features data for prediction of functional disease-associated SNPs.
Briefings in bioinformatics - 18 Jan 2019
Dong Shan-Shan, Guo Yan, Yao Shi, Chen Yi-Xiao, He Mo-Nan, Zhang Yu-Jie, Chen Xiao-Feng, Chen Jia-Bin, Yang Tie-Lin
Abstract excerpt
Genome-wide association studies (GWASs) are an effective strategy to identify susceptibility loci for human complex diseases. However, missing heritability is still a big problem. Most GWASs single-nucleotide polymorphisms (SNPs) are located in noncoding regions, which has been considered to be the unexplored territory of the genome. Recently, data from the Encyclopedia of DNA Elements (ENCODE) and Roadmap...
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