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Article

Regulatory SNPs: Altered Transcription Factor Binding Sites Implicated in Complex Traits and Diseases.

International journal of molecular sciences - 16 Jun 2021

Degtyareva Arina O, Antontseva Elena V, Merkulova Tatiana I

Abstract excerpt

The vast majority of the genetic variants (mainly SNPs) associated with various human traits and diseases map to a noncoding part of the genome and are enriched in its regulatory compartment, suggesting that many causal variants may affect gene expression. The leading mechanism of action of these SNPs consists in the alterations in the transcription factor binding via creation or disruption of transcription...

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Identifiers

PMID: 34208629
DOI: 10.3390/ijms22126454
PMCID: PMC8235176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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