Article
Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations.
PloS one - 1 Jan 2013
Dias Fabrício C, Medina Tiago da S, Mendes-Junior Celso T, Dantas Roberto O, Pissetti Cristina W, Rodrigues Junior Virmondes, Dellalibera-Joviliano Renata, Marin-Neto José A, Gutierrez Fredy R S, Moreau Philippe, Silva João S, Donadi Eduardo A
Abstract excerpt
BACKGROUND: Chagas disease affects approximately 10 million people mainly in Latin America. The immune regulation by the host seems to be an essential factor for disease evolution, and immune system inhibitory molecules such as CTLA-4 and PD-1 favor the maintenance of peripheral tolerance. Considering that polymorphisms at the immunoregulatory CTLA-4 and PDCD1 genes may alter their inhibitory function, we...
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