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Article

FOXP3 gene polymorphisms are associated with indeterminate clinical form of Chagas disease.

Microbes and infection - 1 Jan 2025

Medeiros Nayara I, Oliveira Daniela Silva, Ferreira Karine S, Keesen Tatjana S L, Rocha Luiz Paulo C, Sousa Giovane R, Damasio Marcos P S, Fares-Gusmao Rafaelle C G, Chaves Ana T, De Araújo Fernanda F, Dutra Walderez O, Correa-Oliveira Rodrigo, Rocha Manoel O C, Gomes Juliana A S

Abstract excerpt

The forkhead box protein 3 (FOXP3) transcription factor is the main marker of regulatory T-cell (Treg) development and activation, a subpopulation involved in immune system regulation, self-tolerance, and protection against infections. We previously showed that Treg cells control the exacerbated immune response and morbidity in chronic Chagas disease, by modulating the cytokine environment and killing effector...

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Identifiers

PMID: 40543721
DOI: 10.1016/j.micinf.2025.105544

Genes

FOXP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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