Article

Specific methylation marks in promoter regions are associated to the pathogenic process of Chronic Chagas disease Cardiomyopathy by modifying transcription factor binding patterns

2021-12-21

Abstract excerpt

Chagas disease, caused by Trypanosoma cruzi , is an endemic parasitical disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, including Chronic Chagasic Cardiomyopathy (CCC), which ranges from moderate to severe stages depending on the cardiac ejection fraction. The pathogenic process remains poorly understood, although genetic and epigenetic fact...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b60815d4-347d-52b3-8e10-6f5700270435
DOI: 10.1101/2021.12.20.21267972

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Specific methylation marks in promoter regions are associated to the pathogenic process of Chronic Chagas disease Cardiomyopathy by modifying transcription factor binding patternsDOI 10.1101/2021.12.20.21267972Read

Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathySemantic proximity Read

Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease CardiomyopathySemantic proximity Read

Exploring global and specific pathogenic mechanisms in Chronic Chagas Cardiomyopathy through multi-omics integrationSemantic proximity Read

GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels.Semantic proximity Read

Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular DysfunctionSemantic proximity Read

Chagas Disease Cardiomyopathy: Immunopathology and GeneticsSemantic proximity Read

A Genome-Wide Association Study Identifies Novel Susceptibility loci in Chronic Chagas CardiomyopathySemantic proximity Read

Immunologic changes are detectable in the peripheral blood transcriptome of clinically asymptomatic Chagas cardiomyopathy patientsSemantic proximity Read

miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathySemantic proximity Read

Transcriptome analysis of circulating microRNAs associated with Chagas disease susceptibility and chronic Chagas cardiomyopathy severitySemantic proximity Read

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic TargetsSemantic proximity Read

Differential expression profile of genes involved in the immune response associated to progression of chronic Chagas diseaseSemantic proximity Read