Article
A one-degree-of-freedom test for supra-multiplicativity of SNP effects.
PloS one - 1 Jan 2013
Herold Christine, Ramirez Alfredo, Drichel Dmitriy, Lacour André, Vaitsiakhovich Tatsiana, Nöthen Markus M, Jessen Frank, Maier Wolfgang, Becker Tim
Abstract excerpt
Deviation from multiplicativity of genetic risk factors is biologically plausible and might explain why Genome-wide association studies (GWAS) so far could unravel only a portion of disease heritability. Still, evidence for SNP-SNP epistasis has rarely been reported, suggesting that 2-SNP models are overly simplistic. In this context, it was recently proposed that the genetic architecture of complex diseases...
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