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Article

Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.

International journal of biological sciences - 1 Jan 2021

Zhao Ming, Quan Yingyao, Zeng Jianming, Lyu Xueying, Wang Haitao, Lei Josh Haipeng, Feng Yangyang, Xu Jun, Chen Qiang, Sun Heng, Xu Xiaoling, Lu Ligong, Deng Chu-Xia

Abstract excerpt

Cholangiocarcinoma (CC), the most lethal type of liver cancer, remains very difficult to treat due to an incomplete understanding of the cancer initiation and progression mechanisms and no effective therapeutic drugs. Thus, identification of genomic drivers and delineation of the underlying mechanisms are urgently needed. Here, we conducted a genome-wide CRISPR-Cas9 screening in liver-specific Smad4/Pten knockout...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34803491
DOI: 10.7150/ijbs.67379
PMCID: PMC8579464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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